Rebelling for a Reason: Protein Structural “Outliers”

Analysis of a Problem Using Various Visions

 In this paper an applied problem, where the response of interest is the number of success in a specific experiment, is considered and by various visions is studied. The effects of outlier values of response on results of a regression analysis are so important to be studied. For this reason, using diagnostic methods, outlier response values are recognized. It is shown that use of arc-sine ...

Identification of outliers types in multivariate time series using genetic algorithm

Multivariate time series data, often, modeled using vector autoregressive moving average (VARMA) model. But presence of outliers can violates the stationary assumption and may lead to wrong modeling, biased estimation of parameters and inaccurate prediction. Thus, detection of these points and how to deal properly with them, especially in relation to modeling and parameter estimation of VARMA m...

A New Approximation for the Null Distribution of the Likelihood Ratio Test Statistics for k Outliers in a Normal Sample

Usually when performing a statistical test or estimation procedure, we assume the data are all observations of i.i.d. random variables, often from a normal distribution. Sometimes, however, we notice in a sample one or more observations that stand out from the crowd. These observation(s) are commonly called outlier(s). Outlier tests are more formal procedures which have been developed for detec...

Study of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...

Rebelling against the crowd: Qualitative Example-Finding using Genetic Algorithms with Endogenous Fitness.